Recommended dose antacids and severe hypercalcaemia

Severe hypercalcaemia syndrome with daily low-dose vitamin D supplementation.

Severe Infantile Hypercalcaemia

In 1932 Lightwood described a child aged 2 years whose illness resembled the terminal stages of severe infantile hypercalcaemia. Later Butler (1951) and Fanconi (1951) each reported similar cases and they then discussed their findings in ajoint paper (Fanconi, Girardet, Schlesinger, Butler and Black, 1952). Since then there have been several reports of the severe form of this disease in this co...

Immobilization hypercalcaemia with severe bone mineral loss and hypogonadism.

Moderate hypercalcaemia occurred in a 17-year-old male who was immobilized with abdominal and right hip sepsis for 9 months after a motor vehicle accident. The hypercalcaemia was due to bone resorption, with a urine hydroxyproline:creatinine ratio of 0.203 (normal less than 0.017) and a urine calcium loss of 22.9 mmol/24 hr, associated with impaired renal function. There was radiological eviden...

Reversible cerebellar signs due to sarcoid-related severe hypercalcaemia.

1. Severe and symptomatic hypercalcaemia can occur in sarcoidosis but remains uncommon, <5% of cases (malignancy should remain top of the list in unexplained cases). If rehydration and steroids are unsuccessful, other options are ketoconazole and chloroquine in this context. 2. It is imperative to know the serum calcium level (amongst other electrolytes) in patients with abnormal mentation and ...

Effect of antacids and ranitidine on the single-dose pharmacokinetics of fosamprenavir.

Single doses of MAALOX TC and ranitidine were administered separately with 1,400 mg of fosamprenavir (FPV). MAALOX TC decreased the area under the concentration-time curve from 0 to 24 h (AUC(0-24)) for plasma amprenavir (APV) by 18% and the maximum concentration of drug in serum (C(max)) by 35%; the plasma APV concentration at 12 h (C(12)) increased by 14%. Ranitidine at 300 mg decreased the A...